It was the hosts with Freddie Grant and Louise linking well who had the better start forcing Gate keeper Valerey Pajetat into some fine saves.
The hosts took the lead in the 44th minute as the Gate failed to clear a corner allowing Louise to extend his leg to hook the hosts in front.
A bad injury to Tarik Moore Azille meant he was stretchered off as Margate's afternoon went from bad to worse.
A contentious moment of the Match occurred in the 53rd minute as Margate Striker Michael Thalassitis received two quick yellow cards, the second for apparent dissent ended his afternoon early.
Not many more chances followed with the hosts looking more likely to extend their lead in a frustrating afternoon for the Gate.
MARGATE: Pajetat, Hamilton, Sessegnon, Rogers (c), Moore-Azille (McFarlane 37'), Swift, Ngamvoulou, Evans, Thalassitis, Akindayini, Martin (Fanimo 85')
Subs Not Used: Miles, Palmer